Publish Time: 2023-12-27 Origin: Site
With the development of society, environmental pollution, work pressure, and unhealthy habits have led to more and more people experiencing immune system problems, as well as symptoms of allergies and chronic inflammation.
Common symptoms include allergic rhinitis, which is a disease caused by inhaling external allergenic antigens and characterized by nasal itching, sneezing, and clear mucus. The typical symptoms are mainly paroxysmal sneezing, clear nasal mucus, nasal congestion, and nasal itching. The basic pathological changes include capillary dilation, increased vascular permeability, increased glandular secretion, and eosinophil infiltration. Long term recurrent attacks can cause proliferative changes in the mucosal epithelial layer, leading to mucosal hypertrophy and polypoid transformation, which can evolve into chronic rhinitis.
Allergic rhinitis is a common and important human disease. Clinically, drugs used to treat allergic rhinitis include steroids and antihistamines, but these drugs have significant side effects and are not very suitable for the treatment of allergic rhinitis.
A study from a well-known university in China found that hydrogen negative ions in hydrogen water have the ability to selectively neutralize malignant free radicals such as hydroxyl radicals and nitrite anions, effectively inhibiting inflammation and cell apoptosis. Hydrogen does not affect free radicals such as nitric oxide and hydrogen peroxide, which have signaling effects. In addition, hydrogen is a non-polar neutral molecule with ideal diffusion ability in biological systems, which can quickly enter the mitochondria and nucleus of cells. Saturated hydrogen water is a small molecule water that is more easily absorbed by the whole body. Selective antioxidant activity and strong diffusion ability are powerful advantages that other antioxidant substances do not possess. Research topic: Is hydrogen effective in treating allergic rhinitis in animals.
The above figure shows the immunohistochemistry of eosinophil specific chemokine protein. C represents the rhinitis group, D represents the treatment group, and red represents positive. 32 guinea pigs were randomly divided into 4 groups, with 8 in each group, including a normal control group, a normal hydrogen water group, a nasal hydrogen water treatment group, and a nasal saline control group. An allergic rhinitis animal model was established by sensitization with ovalbumin, and nasal symptoms such as sneezing frequency and scratching frequency were recorded. IgE, blood eosinophil count, and eosinophil cationic protein levels were measured, Serum malondialdehyde and superoxide dismutase were measured as oxidative stress indicators. RT-PCR was used to analyze the mRNA level of eosinophil specific chemokine, while immunoblotting and immunofluorescence were used to analyze the protein level of eosinophil specific chemokine.
Research has found that hydrogen water can reduce reactive oxygen species and serum malondialdehyde levels, increase superoxide dismutase activity, reduce the frequency of sneezing and scratching in animals with allergic rhinitis, and reduce the number of eosinophils in the blood and serum levels of eosinophil specific chemokines. The expression level of eosinophil specific chemokines in the nasal mucosa also significantly decreases. The results indicate that hydrogen water can treat allergic rhinitis in animals by inhibiting the activation of eosinophils, reducing local tissue oxidative stress.
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